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What's up?

 
See:
up
part of speech: phrase
definition: "What's up?" is an informal expression. Sometimes we use it to mean "Hi, how are you?" Sometimes we use it to mean "What's happening?" Sometimes we ask "what's up with" some person. When we ask this, we are usually asking if something is wrong with that person or why they are acting in a way that is different.
Hey! What's up? Haven't seen you for a while.It looks like everybody is upset. What's up?What's up with Jackson? He's in a weird mood today.